ACON Pharmaceuticals

Chemical Supply

ACON Pharma provides nucleoside analogues and derivatives, phosphoramidites, and specialty chemicals for oligonucleotide therapeutics research and pharmaceutical development.

Nucleoside Chemistry

Nucleoside analogues and derivatives have been widely used as anti-tumor and anti-viral medicines. They are the basic units and precursors for oligonucleotide therapeutics such as siRNA, saRNA and mRNA. The modified nucleosides are also used in sequencing kits. Modification of the bases or sugar rings may significantly change the pharmacokinetics and pharmacodynamics properties of nucleoside molecules. Also it could lower the immunogenicity and improve the stability of oligonucleotides.
Nucleoside Chemistry

Our Capabilities

  • Sugar moiety modification including furanose, pyranose, carbocyclic, S-substituted rings, morpholine and acyclic rings
  • Purine, pyrimidine based natural and unnatural bases with various glycosidic bonds
  • Natural or modified monophosphates, diphosphates and triphosphates
  • Phosphoramidites, prodrugs and fluorescent nucleoside derivatives
  • Fully equipped instrument facilities (NMR, LC-MS, HPLC, SFC, MPLC) with quality control system supporting mg to kg scale synthesis

Nucleotides and Nucleosides

Stock products available for immediate shipment.
Nucleotides and Nucleosides

Phosphoramidites

Comprehensive catalog of phosphoramidite building blocks.
Phosphoramidites

Modified Monomers

2'-deoxy, 2'-OMe, 2'-F, 2'-OMOE, LNA, UNA, 2'-TBS, and GNA monomers available.
Modified Monomers

Delivery Vectors & GalNAc Lipids

GalNAC and lipids delivery systems for targeted oligonucleotide delivery.
Delivery Vectors & GalNAc Lipids

Interested in Chemical Supply?

Contact us to learn more about our chemical supply capabilities and how we can support your needs.

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Explore Other Services

Technology Platform

Proprietary drug delivery system technology platforms including LNP, liposome, nanoparticle, and more.

Product Pipelines

RNA therapeutics and small molecule drug pipelines using proprietary LNP inhalation and drug delivery technologies.

Medical Devices

FDA-registered medical devices including Nasasponge dissolvable nasal dressing and HA gel injection and HA Nasal Moisturizing Spray.

Enzyme & RNA Supply

Enzymes, mRNA synthesis reagents, and RNA raw materials for life science and biopharma applications.

Collaboration & Services

Contract development and manufacturing services for drug delivery, siRNA/mRNA design, and nucleic acid chemistry.

GLP-1 Peptides

High-purity Semaglutide peptides for research applications.